小胶质细胞在缺血性脑卒中后活化特点的研究进展

摘要

Microglia,which is the resident immune cells in the brain,is rapidly activated after the occurrence of is chemic stroke.It plays dual roles of nerve injury and repair in the pathological process of ischemic stroke and is a research focus in ischemic stroke in recent years.After cerebral ischemia,microglia is activated rapidly,and the dynamic changes of time and space are presented in the activation process.In the acute and subacute stages of the stroke,mi croglia appears different phenotypes in ischemic core area and peripheral area.Research evidence shows that the phenotype changes of microglia has a significant impact on prognosisof ischemic stroke.In this paper,the basic characteristics of microglia and whose phenotype changes in ischemic stroke are sorted out,in order to provide theoretical support for the new target of the drug research about microglia in anti-ischemic stroke.%小胶质细胞作为脑内常驻的免疫细胞,在缺血性脑卒中发生后快速活化,发挥了神经损伤和修复的双重作用,是近年来缺血性脑卒中研究的热点.研究证据表明,脑缺血后小胶质细胞的活化可呈现时间和空间的动态变化,在脑卒中的急性期、亚急性期,小胶质细胞在缺血中心区和周边区出现不同的表型,其表型的变化对缺血性脑卒中的预后产生了至关重要的影响.本文对小胶质细胞的基本特征及其在缺血性脑卒中中的表型变化进行了梳理,以期为小胶质细胞作为抗缺血性脑卒中药物研究的新靶标提供理论支撑.