江苏部分地区农村妇女HPV感染状况分析

摘要

目的 了解江苏部分地区农村妇女人乳头瘤病毒(HPV)感染状况,预防和减少HPV感染,提高妇女健康水平.方法 选取2012年1～5月在江苏铜山、射阳、泰兴、高邮、兴化和宿豫6个地区,宫颈细胞学涂片筛查结果异常并有宫颈组织病理诊断报告的401例农村妇女作为研究对象,按照宫颈病变程度分为正常/炎症、宫颈上皮内瘤变(CIN)1、CIN2和CIN3四组,采用HPV分型基因芯片检测试剂盒进行HPV DNA分型检测,并对各亚型的感染情况进行分析.结果 387例样本有基因分型检测结果,检出HPV阳性者125例,阳性率为32.30％,其中正常/炎症、CIN1、CIN2和CIN3组HPV阳性检出率分别为32.04％、25.74％、35.16％和36.96％;高危阳性率为23.51％,其中正常/炎症、CIN1、CIN2和CIN3组感染高危HPV检出率分别为18.45％、19.80％、28.57％和28.26％;四组间HPV感染差异无统计学意义(P＞0.05);妇女感染高危HPV亚型前3位为HPV16、HPV58和HPV18.结论 农村妇女高危HPV感染率高,需加强HPV的筛查和接种HPV疫苗,预防和减少宫颈癌的发生.%Objective To understand the infection status of human papilloma virus (HPV) of partial rural females in Jiangsu Province in order to prevent and reduce HPV infection and improve female health level.Methods A total of 401 rural women from Tongshan,Sheyang,Taixing,Gaoyou,Xinghua and Suyu from January to May 2015 were selected,and divided into 4 groups,normal/inflammation group,CIN1 group,CIN2 group and CIN3 group respectively.HPV DNA genotypes were detected and analyzed by genetic chip method.Results One hundred and twenty-five samples were found positive of HPV in 387 samples (eligible) among 401 samples.and the positive rate of HPV was 32.30％.The HPV-positive rates in normal/inflammatory,CIN1,CIN2 and CIN3 groups were 32.04％,25.74％,35.16％ and 36.96％ respectively.The total positive rate of high-risk HPV was 23.51％,and those rates in normal/inflammatory,CIN1,CIN2 and CIN3 groups were 18.45％,19.80％,28.57％ and 28.26％ respectively.There was no statistical difference among the 4 groups (P ＞ 0.05).The top three subtypes were HPV16,HPV58 and HPV18.Conclusion The high-risk HPV infection rate of rural females is high.It is important to enhance HPV screening and HPV vaccination to prevent and reduce cervical cancer.