头孢曲松钠致包皮水肿1例

摘要

2017年10月,1例包皮水肿患者就诊解放军第309医院门诊.发病前,患者因急性上呼吸道感染接受头孢曲松钠静脉滴注治疗,连续用药5d后出现包皮水肿并逐渐加重.结合病史、临床表现、实验室检查、鉴别诊断,患者被诊断为头孢曲松钠所致不良反应性包皮水肿,并给予停用头孢曲松钠、门诊观察、随访等处理措施.停药2d后患者包皮水肿症状逐渐减轻,停药3d后症状完全消失,随访观察28 d症状未再出现.通过对病例的回顾总结提示,头孢曲松钠广泛应用于呼吸道感染、败血症、腹腔感染、肾盂肾炎、盆腔炎性疾病、骨关节感染、皮肤软组织感染、中枢神经系统感染等临床治疗,疗效确切,但其不良反应屡见报道,甚至有严重的病例,不容忽视.为了确保用药安全,在使用头孢曲松钠时,应严格掌握适应证和禁忌证,做好不良反应的监测和及时有效治疗处理.%In October 2017,a patient with edema of the foreskin visited the outpatient clinic of the 309th Hospital of Chinese PLA.Before the onset of the disease,the patient was treated with ceftriaxone sodium intravenous infusion for acute upper respiratory tract infection,edema of the foreskin was found and gradually aggravated after 5 days of continuous medication.Combined with medical history,clinical manifestation,laboratory examination and differential diagnosis,the patient was diagnosed as prepuce edema induced by adverse drug reaction of ceftriaxone sodium,and the treatment measures such as cessation of ceftriaxone sodium,outpatient observation,follow-up were given.The symptoms of edema of the foreskin were gradually reduced after 2 days of withdrawal,and the symptoms disappeared completely after 3 days of withdrawal,and the symptoms were not reappeared for 28 days.Through reviewing and summarizing of cases,ceftriaxone sodium is widely used in respiratory tract infection,septicemia,abdominal infection,pyelonephritis,pelvic inflammatory diseases,bone and joint infections,skin and soft tissue infections,central nervous system infection in patients with clinical treatment,and have exact effect,but its adverse reactions have been reported,even in severe cases,can not be ignored.In order to ensure the safety of drug use,when using ceftriaxone sodium,we should strictly grasp indications and contraindications,do well in monitoring adverse reactions and timely and effective treatment.