宫-腹腔镜术后辅以亮丙瑞林治疗子宫内膜异位症的临床效果

摘要

Objective To investigate the clinical effect in patients of endometriosis associated infertility after laparoscopy combined with hysteroscopy plus leuprorel in treatment.Methods From September 2015 to June 2016,86 cases of endometriosis associated with infertility in the Second Affiliated Hospital of Xinjiang Medical University were selected,according to the different treatments they were divided into two groups:43 cases in control group were given the treatment of laparoscopy combined with hysteroscopy treatment,43 cases in the observation group were given the periodic injection of leuprorel on the basis of the control group.Postoperative follow-up of 1 years,the postoperative of pregnancy curative effect,postoperative life quality and estradiol (E2),carbohydrate antigen (CA125) level of patients in the two groups were compared.Results The effective rate of the observation group was higher than that of the control group,and the recurrence rate was lower than that of the control group.the difference was statistically significant (P ＜ 0.05).The pregnancy rate of the observation group was better than that of the control group,and the difference was statistically significant (P ＜ 0.05).There was no significant difference in quality of life score,VAS score,and the level of E2 and CA125 between the two groups before treatment (P ＞ 0.05),and obviously improved after treatment,the differ ences were statistically significant (P ＜ 0.05).Conclusion Laparoscopy combined with hysteroscopy plus leuprorel treat endometriosis associated with infertility is better than simple surgery,and to a certain extent can reduce the recurrence rate,increase the pregnancy rate,and improve the quality of life of endometriosis.%目的 探讨宫-腹腔镜术后辅以亮丙瑞林治疗子宫内膜异位症的临床效果.方法 选择2015年9月～2016年6月新疆医科大学第二附属医院术后确诊为子宫内膜异位症伴不孕的患者86例,根据不同治疗方案分为两组,对照组43例,采用宫-腹腔镜手术治疗;观察组43例,在对照组基础上术后月经周期应用亮丙瑞林治疗,术后随访1年.比较两组患者术后疗效、妊娠结局、生活质量及雌二醇(E2)、糖类抗原125(CA125)水平.结果 观察组有效率高于对照组,复发率低于对照组,差异有统计学意义(P＜0.05);观察组的妊娠率高于对照组,差异有统计学意义(P＜0.05);治疗前两组生活质量评分、视觉模拟评分、E2水平、CA125水平比较,差异无统计学意义(P＞0.05);治疗后,两组患者治疗后均较治疗前明显改善,差异均有统计学意义(P＜0.05).结论 宫腹腔镜术后辅以亮丙瑞林治疗子宫内膜异位症伴不孕效果优于单纯手术治疗,一定程度上可降低复发率,提高子宫内膜异位症不育患者的妊娠率,改善生活质量.