糖化血红蛋白测定在2型糖尿病肾病中的诊断价值

摘要

目的：探讨糖化血红蛋白与尿微量白蛋白对早期诊断2型糖尿病肾病的价值。方法：对42例糖尿病患者进行空腹血糖(FBG)、糖化血红蛋白(HbAlc)、尿微量白蛋白(m-ALB)、胆固醇(CHo)、甘油三脂(TG)、高密度脂蛋白胆同醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及血常规测定，并将结果与健康对照组进行比较。按糖化血红蛋白的测定结果分为低值组(HbAlc＜6.79％)、中值组(HbAIc 6.8％～10％)、高值组(HbAlc＞10.1％)。结果：糖尿病患者HbAIc、FBG、CHo、TG、LDL-C的血清浓度明显高于健康对照组，HDL-C的血清浓度明显低于健康对照组。随着HbAIc的增高，FBG、m-ALB随之增高。结论：糖尿病肾病与HbAlc的增高有关，血脂异常可增加糖尿病患者肾病微血管病变的危险性。m-ALB是糖尿病早期肾小球损伤标志物，可作为慢性肾病的筛查指标。同时联合检测糖尿病患者糖化血红蛋白与尿微量白蛋白有利于糖尿病肾病的早期检出，延缓糖尿病肾病的进展。%Objective: To investigate the HbA1c and urinary albumin in early diagnosis of diabetic nephropathy in type 2 diabetes mellitus value. Methods:In 42 patients with diabetes and fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), microalbuminuria (M-ALB), cholesterol (CHo), glycerin three greases (TG), high density lipoprotein cholesterol with alcohol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood routine determination, and the results compared with healthy controls. According to the determination result of glycosylated hemoglobin for low value group (HbAlc<6.79%), median group (HbAIc 6.8%~10%), higher values in the group (HbAlc>10.1%). Results:The diabetes patient's HbAIc, FBG, CHo, TG, LDL-C concentrations were significantly higher than healthy control group, the serum HDL-C concentration was significantly lower than that of the control group. The difference was statistically significant. With the increase of HbAIc. FBG, m-ALB increased. Conclusion: Diabetic nephropathy is associated with increased HbAlc. Dyslipidemia can increase in microvascular lesions in diabetic nephropathy risk. M-ALB diabetes is early glomerular injury markers. I can be used as the screening index of chronic nephropathy. Combined detection of glycosylated hemoglobin of diabetes and microalbuminuria in favor of diabetic nephropathy early detection, delay the progression of diabetic nephropathy.