溃疡性结肠炎及克罗恩病的病理形态学特点对比研究

摘要

目的：对比研究溃疡性结肠炎(UC)与克罗恩病(CD)的病理形态学特点。方法：将诊断为UC和CD的181例患者病例资料进行回顾性分析，根据实验室与临床资料，比较其镜下及组织学表现的不同。结果：经过结肠镜下比较发现，病变部位、分布状态、纵行溃疡、环形溃疡、阿弗他溃疡、结节样增生、肠腔狭窄及鹅卵石征等项目在两组患者间的比较其差异显著，而其他类型则无差异。两组患者的病理结果比较发现，炎症侵犯肌层、绒毛状结构增生、隐窝炎或脓肿、非干酪性肉芽肿、隐窝扭曲、杯状细胞减少以及潘氏细胞化生等项目组间差异显著。结论：根据UC和CD的病理学特点，在诊断UC和CD时需要将内镜下和显微镜下结肠病变的特征进行综合分析，以便做出更为准确的诊断。%Objective:Comparative study on ulcerative colitis and Crohn's disease pathological features.Methods: The March 2009 to February 2012 in our hospital diagnostics to clinical data of patients with ulcerative colitis and Crohn's disease were analyzed retrospectively, based on my medical record system to extract the hospital laboratory and clinical data of patients with the study, comparison of endoscopic and histological its different manifestations.Results:After comparing colonoscopy found lesions, distribution, longitudinal ulcers, circular ulcers, aphthous ulcers, nodular hyperplasia, intestinal symptoms such narrow cobblestone projects with significant differences between the two groups of patients in comparison, whereas no significant difference in other types. To compare the two groups of patients with pathological results found violations of the muscle inflammation, villous structures hyperplasia, crypt inflammation or abscess, non-caseating granulomas, crypt distortion, goblet cells decreased, the Paneth cell metaplasia and other project team the difference was significant, with statistical significance. Conclusion: Endoscopic features of colonic lesions under the microscope and the need to conduct a comprehensive analysis in the diagnosis of ulcerative colitis and Crohn's disease, and in order to make a more accurate diagnosis.