氟牙症未成年患者全身氟代谢状况与口腔氟含量的相关性研究

摘要

目的 探讨氟牙症未成年患者全身氟代谢状况与口腔氟含量的关系.方法 选取贵州省毕节市织金县2个中学的168名在校学生为调查对象,采用Dean分类方法检查氟牙症状况,据此分为正常组、轻度组、中度组及重度组.采用离子选择性电极法测定尿液、唾液及菌斑的氟含量.采用Pearson相关系数、Kendall's tau-b等级相关系数、双量偏相关系数分析氟牙症严重程度与氟含量的关系.结果 全部调查对象中被诊断为氟牙症者41例,发生率为24.4%,其中轻度、中度及重度分别为18例(43.9%)、14例(34.1%)、9例(22.0%).调查对象的唾液、菌斑及尿液的平均氟含量水平分别为(3.360±1.227)mg/L、(29.515±6.133)μg/g、(1.119±0.870)mg/L.正常组的唾液、菌斑及尿液的氟含量均小于其他组,轻度组的各指标氟含量低于中度组和重度组,中度组的各指标氟含量均小于重度组.Pearson相关分析表明氟牙症患儿的唾液、菌斑及尿液氟含量两两均呈正相关(P<0.05).Kendall's tau-b相关分析结果表明,氟牙症严重程度与唾液、菌斑及尿液氟含量的相关系数分别为0.871、0.902和0.515.双量偏相关分析结果表明,在控制氟牙症严重程度与菌斑氟含量后,唾液氟含量与尿液氟含量之间呈正相关(P<0.05),氟牙症严重程度与尿液氟含量之间呈正相关(P<0.05).结论 氟牙症患儿的尿液氟含量与氟牙症严重程度、唾液及菌斑的氟含量均相关.%Objective To investigate the relationship between the metabolism of fluoride in body and oral fluoride repository in adolescents with dental fluorosis. Methods Totally 168 students in two middle schools of Zhijin County in Guizhou Province were enrolled for the investigation. Dean classification method was used to examine the degree of dental fluorosis, thus they were divided into normal group, mild group, moderate group and severe group. Fluoride ion specific electrode was performed to measure the fluoride levels in urine, saliva and dental plaque. Pearson correlation coefficient, Kendall tau-b correlation coefficient and double partial correlation coefficient were used to analyze the relationship between the degree of dental fluorosis and fluorine content. Results In all cases, 41 cases were diagnosed as fluorosis, whose incidence rate was 24.4%, including 18 mild cases (43.9%), 14 moderate cases (34.1%) and 9 severe cases (22.0%). The average fluoride content of saliva, dental plaque and urine was (3.360 ± 1.227) mg/L, (29.515 ± 6.133) μg/g and (1.119 ± 0.870) mg/L respectively. The fluoride content of saliva, dental plaque and urine in the normal group was significantly lower than that in the other groups, and the content in the mild group was significantly lower than that in the moderate group and the severe group, and the content in the moderate group was significantly lower than that in the severe group (P <0.05). Result of Pearson correlation analysis showed that the fluoride content of saliva, dental plaque and urine were correlated with each other in adolescents with dental fluorosis (P <0.05). Result of Kendall's tau-b correlation analysis showed that the correlation coefficients between the severity of dental fluorosis and fluoride content of saliva, dental plaque and urine were 0.871, 0.902 and 0.515 respectively (P < 0.05). Double partial correlation coefficient analysis showed that after controlling the severity of dental fluorosis and fluoride content of plaque, the fluoride content of saliva was positively correlated with the fluoride content of urine (P <0.05); after controlling the fluoride content of saliva and plaque, the severity of dental fluorosis was positively correlated with fluoride content of urine (P <0.05). Conclusions Fluoride content of urine in adolescents with dental fluorosis is significantly related to the severity of dental fluorosis, fluoride content of saliva and dental plaque.