目的 探讨P53、Her-2和Ki67在甲状腺乳头状癌中的表达及临床意义.方法 采用免疫组织化学法,分别研究128例甲状腺乳头状癌肿瘤组织,56例甲状腺腺瘤组织,以及9例正常甲状腺组织标本中P53、Her-2和Ki67的表达.结果 P53、Her-2和Ki67在正常甲状腺组织中无阳性表达.甲状腺乳头状癌组织中P53阳性表达率为85.15％(109/128),高于腺瘤组织的26.78％(15/56)(P<0.05).甲状腺乳头状癌组织中Her-2阳性表达率为25.78％(33/128),高于腺瘤组织的12.49％(7/56)(P<0.05).甲状腺乳头状癌和腺瘤组织中的Ki67阳性率分别为38.28％(49/128)和23.21％(13/56),差异无统计学意义(P>0.05).结论 P53、Her-2对临床评估甲状腺乳头状癌的发生、发展及预后有一定指导意义,Ki67对鉴别甲状腺乳头状癌无明确临床意义.%Objective To investigate the expressions of p53, Her-2 and Ki67 in thyroid papillary carcinomas (TPC) and their significance. Methods The expressions of p53, Her-2 and Ki67 in 128 cases of TPC, 56 cases of thyroid adenomas and 9 cases of normal thyroid tissues were detected by immunohistochemical technique. Results There was no positive expression of p53, Her-2 or Ki67 in the normal thyroid tissues. The positive expression rate of p53 in the TPC was 85.15％ (109/128) which was significantly higher than 26.78％ (15/56) of the thyroid adenomas (P < 0.05). The positive expression rate of Her-2 in the TPC was 25.78％ (33/128) which was significantly higher than 12.49％ (7/56) of the thyroid adenomas (P < 0.05). The positive rates of Ki67 expression in the TPC and the thyroid adenomas were 38.28％ (49/128) and 23.21％ (13/56) respectively, the statistical analysis showed no significant difference between the two groups (P > 0.05). Conclusions P53 and Her-2 expressions have certain guiding significance for the evaluation of the occurrence, development and prognosis of thyroid papillary carcinoma. Ki67 has no definite clinical significance in differential diagnosis of TPC.
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