黄芪颗粒联合复方甘草酸苷治疗斑秃疗效评价

摘要

Objective:To assess the clinical efficacy and the impact of astragalus particles on T lympho-cyte subsets in peripheral blood among the patients with alopecia areata. Methods:A total of 113 patients with AA were recruited and divided into treatment group ( group A) and control group ( group B) . Oral compound glycyrrhizin tablets, 50 mg/time and 3 times a day, was prescribed to the patients in group B and oral com-pound glycyrrhizin tablets in a combination astragalus granule, 4 g/time and 2 times a day were given to the patients in group A. The treatment course was 3 months for both groups. The T lymphocyte subsets in peripher-al blood was detected by flow cytometry. Results: The recovery rate and the recurrence rate of the treatment group were superior to the control group (P<0.01 and P <0.01). CD4+T cells increased significantly in the treatment group, compared with the results before treatment and the control group after treatment. The differ-ences were statistically significant ( P<0.05 and P<0.01) . Conclusion:Astragalus granule combined with om-pound gycyrrhizin is effective in the treatment of alopecia areata.%目的：评价黄芪颗粒对斑秃患者临床疗效和外周血T细胞亚群的影响。方法：对照组55例口服复方甘草酸苷片,50 mg/次,日3次。治疗组58例,加服黄芪颗粒,4 g/次,日2次,疗程共3个月。流式细胞仪检测斑秃患者外周血T细胞亚群的变化。结果：治疗组痊愈率、复发率优于对照组(P<0.01)。治疗后CD4＋T细胞明显高于疗前和对照组,(P<0.05；P<0.01)。结论：黄芪颗粒联合复方甘草酸苷治疗斑秃有效。