儿童荨麻疹患者过敏原特异性IgG和IgE检测结果分析

摘要

Objective:To analyse the test results of the serum allergen-specific IgG and IgE in children with urticaria. Methods:A total of 63 children with urticaria were enrolled in the study. Then serum specific IgG and IgE were detected by ELISA and western blot. Results: The positivity rate of specific IgG was 76.19% (48/63) and the main allergens were egg and milk. The positivity rate of specific IgE was 41.27%and the main food allergens were egg and fresh water fish. There was a significant difference between the tes-ting results of the specific IgG and IgE for food-allergens ( P=0.000) . The positivity rate of specific IgE was 57.14% and the main inhalation allergens were dust mites and cockroach. There was no significant difference in the positivity rates of the different tests between the age group of the patients. Conclusion: The combined use of serum allergen-specific lgG and IgE detection can help clinicians to find associated allergens, which may provide a basis for the prevention and treatment of children urticaria.%目的：：分析儿童荨麻疹患者过敏原血清特异性IgG和IgE检测结果。方法：对63例儿童荨麻疹患者采用酶联免疫法检测食物过敏原特异性IgG,采用免疫印迹法检测食物及吸入性过敏原特异性IgE。结果：食物过敏原IgG的总阳性率为76.19％,其中主要过敏原是鸡蛋、牛奶；食物过敏原IgE的总阳性率为41.27％,其中主要过敏原是鸡蛋、淡水鱼；食物过敏原IgG和IgE的检测结果不一致( P＝0.000)。吸入性过敏原IgE的总阳性率为57.14％,其中主要过敏原是尘螨和蟑螂。不同年龄组患儿过敏原阳性检出率无明显差异。结论：针对儿童荨麻疹患者进行血清特异性IgG和IgE抗体进行联合检测,有助于明确过敏性皮肤病的过敏原,对临床过敏性疾病的预防和治疗具有重要意义。