多囊卵巢综合征皮肤表现与生物学指标的相关性研究

摘要

Objective:To evaluate the relationship between serum total testosterone ( TT) , free androgen index ( FAI) with polycystic ovary syndrome ( PCOS) . Methods:The levels of TT and FAI of 45 patients with polycystic ovary syndrome and 42 healthy controls were detected by chemiluminescence apparatus. The hirsut-ism, severity of acne and androgenic alopecia were assessed by Ferriman-Gallwey ( M-FG) score, Global Acne Grading System ( GAGS) and Ludwig classication method respectively. Results:The sensitivity and spe-cificity of FAI for hirsutism, acne and androgenic alopecia were 80. 2%, 68. 9% and 60. 3%, and 41. 5%, 49.2% and 36.8%, respectively. The sensitivity and specificity of TT were 20.6%, 21.4% and 29.8%, and 46.5%, 44.8% and 58.3% respectively. Conclusion:The hirsutism, severity of acne and androgenic alopecia were closely related with FAI, but the correlation with TT was low. So FAI can be used as a screening bio-chemical markerin the diagnosis of PCOS.%目的：：评价多囊卵巢综合征( PCOS)患者皮肤表现与血清总睾酮( TT)、游离睾酮指数(FAI)等生化指标的相关性。方法：检测45例PCOS和42例正常对照者的TT、FAI等激素水平。应用改良M－FG标准、痤疮评分系统和Ludwig方案对患者多毛症、痤疮和雄激素性脱发的严重程度进行评分和分级。结果： FAI对多毛症、痤疮和雄激素性脱发的敏感度和特异度分别为80.2％,68.9％,60.3％和41.5％,49.2％,36.8％,明显高于TT的20.6％,21.4％,29.8％和46.5％,44.8％,58.3％。结论：多毛症、痤疮和雄激素性脱发与FAI异常紧密相关,而与TT相关性较低,因此FAI可作为筛查高雄激素血症的重要指标。