腹腔镜与开腹手术对早期宫颈癌患者疗效及生存质量比较研究

摘要

[Objective] To compare the clinical effects and quality of life after combination therapy of laparotomic or laparoscopic surgeries and radiotherapy in early cervical cancer.[Methods] 144 patients with early cervical cancer were divided into laparotomic group and laparoscopic group.The former received laparotomic radical hysterectomy while the later received laparoscopic radical hysterectomy.All patients received radiotherapy after surgeries.Recurrence rate,survival rate and FACT-G score were observed and compared between two groups 1～5years after treatments.[Results] There were no significant differences of recurrence and survival rate between laparotomic and laparoscopic groups 1 ～5 years after treatments.FACT-G scores in laparoscopic group were significantly higher than laparotomic group 1～5 years after treatments (all P ＜0.05).[Conclusions] Clinical effects were equivalent of laparotomic and laparoscopic surgeries,but laparoscopic surgeries improved quality of life better than laparotomic ones.%目的 观察并比较腹腔镜及开腹宫颈癌根治术联合术后放疗患者临床疗效及生活质量.方法 将144例早期宫颈癌患者平均随机分为开腹组与腔镜组,每组各72例.开腹组接受传统经腹宫颈癌根治术,腔镜组接受腹腔镜宫颈癌根治术治疗,术后均予以放射治疗.观察并比较两组患者术后1～5年逐年肿瘤复发率、生存率及癌症治疗功能总体评价量表(FACT-G)评分情况.结果 与开腹组相比,腔镜组术后1～5年肿瘤复发率及生存率差异无显著性(P＞0.05)；与开腹组相比,腔镜组术后1～5年FACT-G评分均显著高于开腹组,且差异均具有显著性(均P ＜0.05).结论 腹腔镜与开腹手术联合术后放射治疗对早期宫颈癌疗效相当,但术后短期及长期生存质量腹腔镜显著优于开腹手术.