血管内皮生长因子基因多态性与2型糖尿病视网膜病变相关性的Meta分析

摘要

目的：利用Meta分析探讨血管内皮生长因子1（Vascular endothelial growth factor，VEGF）基因多态性与2型糖尿病视网膜病变的相关性。方法电子检索CNKI、万方及PubMed数据库，收集有关VEGF 936C/T及VEGF 460C/T基因多态性与2型糖尿病视网膜病变的病例对照研究。检索时间为建库至2013年9月。采用RevMan5.0软件进行Meta分析。结果共纳入9个研究，其中5个研究的是VEGF 936C/T多态性与2型糖尿病视网膜病变的关系，4个研究的是VEGF 460C/T与2型糖尿病视网膜病变的关系。 Meta分析结果显示：具有VEGF 460TT 基因型[OR=0.31，95%CI（0.19，0.50），P＜0.01]，CT 基因型[OR=0.67，95%CI （0.46，0.98），P=0.04]及TT+CT基因型[OR=0.43，95%CI（0.27，0.69），P=0.0005]的人群发生2型糖尿病视网膜病变的风险明显低于具有基因型CC的人群，另外VEGF 460T等位基因携带者2型糖尿病视网膜病变发病风险低于等位基因C携带者[OR=0.67，95%CI（0.55，0.81），P＜0.01]。而VEGF 936C/T多态性在病例组和对照组分析差异无统计学意义（P＞0.05）。结论 VEGF 460C/T基因多态性与2型糖尿病视网膜病变发病相关， VEGF 460C/T基因可能是2型糖尿病视网膜病变的遗传保护因素。%[ABSTRACT]OBJECTIVE To investigate the association between the polymorphism of Vascular endothe-lial growth factor (VEGF) gene and susceptibility of diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM)via meta-analysis. METHODS An electronically search based on CNKI, Wanfang database and PubMed from their establishment to January 2013 was performed to collect case-control studies on VEGF 936C/T and VEGF 460C/T polymorphism and DR in T2DM. RevMan5.0 was used for this study. RESULTS Nine case-con-trol studies were identified (five eligible studies were analyzed for VEGF 936C/T polymorphism and DR in T2DM and fore were analyzed for VEGF 460C/T polymorphism and DR in T2DM ) on association of VEGF polymorphism and DR in T2DM. The results of meta-analysis showed that the population having the genotype VEGF 460TT [OR=0.31,95%CI (0.19,0.50),P<0.00001], genotype CT [OR=0.67,95%CI (0.46,0.98)and TT+CT [OR=0.43,95%CI (0.27,0.69),P=0.0005] presented an decreased DR risk compared to that with the genotypes CC. Moreover the al lele T showed significant association with decreased DR risk compared to the allele C [OR=0.67,95%CI(0.55,0.81), P<0.00001]. While,no significant association was observed on the VEGF 936C/T polymorphism and DR in T2DM (P>0.05). CONCLUSIONS VEGF 460C/T polymorphisms was associated with DR in T2DM and VEGF 460C/T variation which might be a genetic protective factor for DR in T2DM.