OBJECTIVE To observe the clinical efficacy of combined TCM therapy in the treatment of primary retinitis pigmentosa (RP). METHODS Patients with primary retinitis pig-mentosa who met the diagnosis and inclusion criteria were treated with traditional Chinese medicine and acupuncture for 3 months. In addition, patients were also treated with puerarin in-jection intravenous infusion for 2 weeks, once half a year, in 3 consecutive years. And follow-up was performed as well. RESULTS A total of 35 cases (70 eyes) were included. During the trial, 3 cases fell off, and the total effective rate of 32 patients (64 eyes) was 55.37％. After treatment, the visual acuity (ETDRS visual acuity score) was improved, and the variation was of statistical differ-ence (P<0.05). The average sensitivity (MS) of the visual field after treatment was improved signifi-cantly (P<0.05). But there was no statistical difference observed in mean defect of visual field after treatment (P>0.05). CONCLUSIONS The cyclical treatment with combined traditional Chinese medicine on primary retinitis pigmentosa yielded a favorable effect in terms of visual acuity and vi-sual field, and the relationship between the treatment plan and the effect of RP worth further ex-ploring.%目的 观察中医综合疗法周期性治疗原发性视网膜色素变性(RP)的临床疗效.方法 对符合诊断及纳入标准的原发性视网膜色素变性患者采用中药、针刺,疗程3个月,联合葛根素注射液静脉滴注的综合性治疗2周,每半年治疗1次,连续3年并进行随访.结果 共纳入35例(70只眼),期间有3例脱落,最终32例患者(64只眼)总有效率为55.37％,治疗后视力(ETDRS视力评分)有所提高,具有统计学意义(P<0.05),治疗后视野平均敏感度(MS)有所提高,具有统计学意义(P<0.05),但治疗前后视野平均缺损(MD)比较,无统计学意义(P>0.05).结论 中医综合疗法周期性治疗原发性视网膜色素变性针对视力及视野等指标的改善具有较好疗效,该治疗方案与RP的时效及量效关系值得进一步探索.
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