ObjectiveTo analyze reasons of myocardial injury and to explore the functional mechanism of vitamin D3 and myocardial injury through researches of serum cardiac troponin T(cTnT)and vitamin D3 in non-dialysis chronic kidney disease(CKD)patients.Methods Cross-sectional study was applied. The clinical data of 443 inpatients without dialysis CKD from stage 2 to 5 were analyzed retrospectively. And comparisons between groups and lineal regression analysis were utilized to investigate the relationship between serum vitamin D3 and cTnT. Results(1)Except patients of CKD1,average cTnT in CKD2-5 were(0.114±0.093)ng/ml,(0.166±0.110)ng/ml,(0.193±0.160) ng/ml,and(0.218±0.140)ng/ml,which were higher than control group (0.038±0.016)ng/ml.Compared with the control group,the difference was statistically significant(P<0.05). However,the level of CK-MB in patients with CKD has no obvious rise,P>0.05. (2)With vitamin D decreasing from normal to lack in CKD3,the level of cTnT increased from(0.148±0.120)ng/ml to(0.198±0.140)ng/ml. Compared with normal control group(0.038±0.016)ng/ml,the difference was statistically significant(P<0.05). However,the level of CK-MB in patients with CKD has no obvious rise,P>0.05.(3)The average cant gradually increased with the reduction of vitamin D in CKD3,which showed a negative correlation(r=-0.105,P<0.05).Conclusion(1)Myocardial injuries exist in CKD2-5 and will exacerbate with CKD stage aggravation. cTnT can be used as a reaction index of myocardial injury.(2)With multiple biological effects, vitamin D could play a certain role in the protection of myocardial injury.%目的:通过对慢性肾脏病(CKD)非透析患者中心肌肌钙蛋白T(cTnT)和活性维生素D3水平的研究,分析心肌损伤的原因,探讨活性维生素D3与心肌损伤的可能作用机制。方法对443例CKD 2~5期非透析患者的临床资料进行回顾性分析。使用组间比较、单因素线性回归分析探讨血清cTnT与维生素D3之间的关系。结果(1)除CKD1期患者外,CKD 2~5期的cTnT的均值分别为(0.114±0.093) ng/ml、(0.166±0.110)ng/ml、(0.193±0.160)ng/ml、(0.218±0.140)ng/ml,均高于对照组(0.038±0.016)ng/ml,与对照组相比,P<0.05;而CKD患者中CK-MB水平无明显升高,与对照组相比,P>0.05。(2)在CKD 3期中,随着维生素D水平从正常到缺乏,cTnT的水平从(0.148±0.120)ng/ml到(0.198±0.140)ng/ml逐渐升高,与对照组均值(0.038±0.016)ng/ml相比,P<0.05。而CK-MB的均值水平无明显变化,与对照组相比,P>0.05。(3)在CKD 3期中,随着维生素D的降低,平均cTnT水平逐渐增高,两者呈负相关(r=-0.105, P<0.05)结论(1)CKD患者心肌损伤存在CKD患者各期,且随着CKD分期逐渐加重,心肌损伤逐渐加重,cTnT可作为一个反应心肌损伤的指标。(2)维生素D具有多效的生物学效应,在心肌损伤的保护中有一定的作用。
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