2型糖尿病肾病患者D-二聚体及胆红素的测定及临床意义

摘要

目的：探讨2型糖尿病肾病患者D-二聚体及胆红素的测定及临床意义。方法本次研究中的119例研究对象均为2014年1月～2016年3月我院收治的2型糖尿病肾病患者并将其作为观察组。对照组50例，均为同期来我院进行健康体检的健康研究对象。将观察组进行再次分组：正常蛋白尿组（NA，n=51）、微量白蛋白尿组（MA，n=43）、大量白蛋白尿组（OA，n=25）。对四组D-二聚体、TBIL、DBIL、IBIL水平进行检测及对比分析。结果观察组D-二聚体高于对照组，TBIL、DBIL、IBIL水平低于对照组，差异有统计学意义（P＜0.05）。MA、OA组D-二聚体水平高于NA组，TBIL、DBIL、IBIL水平低于NA组，OA组D-二聚体水平高于MA组，TBIL、DBIL、IBIL水平低于MA组，差异有统计学意义（P＜0.05）。结论 D-二聚体及胆红素对于2型糖尿病肾病患者的诊断具有重要的临床价值，有利于糖尿病肾病的早期诊断及病情的控制，使致残率及致死率降低。%Objective To investigate bilirubin and serum D-dimer and its clinical significance of patients with diabetic nephropathy.Methods 119 cases of Type 2 diabetic nephropathy were selected from January 2014 to March 2016 in our hospital and as the observation group,and the control group of 50 cases were carried to our hospital over the same period health study physical examination. The observation group were again divided into three groups:normal albuminuria group(NA,n=51),microalbuminuria group (MA,n=43),macroalbuminuria group(OA,n=25). D- dimer,TBIL, DBIL,IBIL level of four groups were detected and compared.ResultsD-dimer of observation group was higher,TBIL,DBIL,IBIL level was lower than the control group,the difference was statisticaly significant(P<0.05). D- dimer levels of MA,OA group was higher than NA group, TBIL,DBIL,IBIL was lower than NA group,D- dimer levels of OA group was higher than MA group,TBIL,DBIL,IBIL was lower than MA group,the difference was statisticaly significant(P<0.05).Conclusion D-dimer and bilirubin for the diagnosis of type 2 diabetic nephropathy patients has important clinical value,is conducive to the early diagnosis of diabetic nephropathy and control the disease,so that reduce the rate of disability and mortality.