比较阿德福韦酯片与拉米夫定片治疗老年慢性乙肝患者的远期疗效

摘要

目的：比较阿德福韦酯片与拉米夫定片治疗老年慢性乙肝患者的远期疗效。方法选取我院收治的80例老年慢性乙肝患者作为观察对象，随机分为对照组与观察组2组，对照组给予拉米夫定片治疗，观察组给予阿德福韦酯片治疗。治疗2年后，将2组患者的血清乙肝 E 抗原（HBeAg）转阴率、血病毒转阴率、粒细胞降低率、肝功能指标复常率、HBV 脱氢核糖核酸（HBV-DNA）水平抑制率进行对比。结果观察组患者的 HBeAg 转阴率、血病毒转阴率、肝功能指标复常率均高于对照组患者（P ＜0.05）；观察组患者的 HBV-DNA 水平抑制率高于对照组患者（P ＜0.05）。结论对老年慢性乙肝患者，对其采取阿德福韦酯片治疗，远期疗效比采用拉米夫定片治疗效果好。%Objective To compare the long-term efficacy of adefovir dipivoxil tablets and lamivudine tablets in treatment of elderly patients with chronic hepatitis B. Methods A total of treated in our hospital 80 cases of elderly patients with chronic hepatitis B patients as observation objects and randomly assigned to control group and observation group 2,lamivudine treatment was given to the control group,the observation group given adefovir dipivoxil tablets in the treatment. Treatment after 2 years,the patients in the two groups of serum hepatitis B e antigen(HBeAg)negative rate,blood virus clearance rate,granulocyte decreased rate,liver function indexes of negative rate,HBV dehydrogenation ribonucleic acid(HBV-DNA)level of inhibition rate were compared. Results The observation group of patients with HBeAg negative rate,blood virus clearance rate,liver function indexes of negative rate were significantly higher than those in the control group(P < 0.05),to observe the HBV-DNA level in patients with inhibition rate was higher than that of the control group(P < 0.05). Conclusion The senile patients with chronic hepatitis B and to take adefovir dipivoxil tablets in the treatment,long-term curative effect obviously compared with lamivudine treatment effect.