儿童克罗恩病与溃疡性结肠炎抗氧化物浓度检测的临床意义

摘要

Objective To investigate the clinical significance of antioxidant concentration detection in children with crohn's disease and ulcerative colitis.Methods From Jan 2011 to Jul 2015,a total of 37 children with inflammatory bowel disease in our hospital were selected as observation group,and another 37 children accepted physical examination in our hospital at the same period were randomly selected as control group. The antioxidant concentration in blood of these two groups,including glutathione peroxidase,whole blood glutathione,VitE and VitC,were detected and compared.ResultsThe concentration of glutathione peroxidase,glutathione and VitE in the observation group was significantly higher than that in the control group,however,the concentration of VitC in the observation group was significantly lower than that in the control group,and their diferences were statisticaly significant(P<0.05).ConclusionCompared with healthy children,the antioxidant concentration of glutathione peroxidase,whole blood glutathione and VitE and VitC,etc. in blood of children with crohn's disease and ulcerative colitis had significant diference,and it can be used as a disease predictor in clinical detection.%目的：探析儿童克罗恩病与溃疡性结肠炎抗氧化物浓度检测的临床意义。方法选择我院2011年1月～2015年7月收治37例炎症性肠病患儿作为研究观察组，另从同期于我院接受健康体检儿童中随机抽取37例作为对照组。测定两组血中谷胱甘肽过氧化物酶、全血谷胱甘肽、VitE、VitC等抗氧化物浓度并进行比较。结果观察组谷胱甘肽过氧化物酶、谷胱甘肽、VitE浓度均高于对照组，而VitC则低于对照组，差异均有统计学意义（P＜0.05）。结论儿童克罗恩病与溃疡性结肠炎血中谷胱甘肽过氧化物酶、全血谷胱甘肽、VitE、VitC等抗氧化物浓度与健康儿童之间存在差异，可作为疾病预测指标应用于临床检测。