探讨奎硫平与利培酮治疗老年精神分裂症的疗效与安全性对比

摘要

目的：探讨老年精神分裂症患者接受奎硫平与利培酮治疗的效果和安全性。方法我院对88例老年精神分裂症患者进行研究分析，将患者分组为对照组和观察组，均有44例，观察组使用奎硫平治疗，对照组则给予利培酮治疗，比较两组的临床治疗效果。结果观察组的临床治疗有效率是93.18%，对照组的临床治疗有效率是91.91%，两组结果对比差异不存在统计学意义（P＞0.05）；观察组的治疗依从性是95.45%，对照组的临床治疗依从性是77.67%，结果差异存在统计学意义（P＜0.05）；观察组不良反应发生率是25.00%，对照组的不良反应发生率是58.82%，结果差异存在统计学意义（P＜0.05）。结论奎硫平与利培酮对老年精神分裂症患者的治疗效果均比较突出，患者使用奎硫平的依从性较高，不良反应率较低，安全性更高。%Objective To investigate the efifcacy and safety of quetiapine and risperidone in the treatment elderly patients with schizophrenia receiving. Methods88 cases of elderly patients with schizophrenia in our hospital were analyzed, patients were divided into control group and observation group, 44 cases in observation group, quetiapine treatment, control group were given risperidone treatment, clinical therapeutic effects were compared between the two groups.Results The clinical effective rate in the treatment group was 93.18%, the effective rate of treatment group was 91.91%, comparing the two groups results there were signiifcant differences (P> 0.05); treatment compliance of the observation group was 95.45%, clinical treatment compliance and control group was 77.67%, the results are statistically difference (P< 0.05); the observation group of adverse reaction probability was 25.00%, the probability of adverse reactions of the control group was 58.82%. There were signiifcant differences (P< 0.05). Conclusion Quetiapine and risperidone in the treatment of elderly patients with schizophrenia treatment effects were more prominent in patients with quetiapine high adherence, lower adverse reaction rate, higher security.