加巴喷丁与卡马西平治疗原发性三叉神经痛的临床疗效及不良反应观察

摘要

Objective Analyze the clinical curative effect and adverse reaction of Gabapentin and carbamazepine in the treatment of primary trigeminal neuralgia.Methods 60 cases of primary trigeminal neuralgia patients in our hospital of as the research object, according to the treatment of the different divided into research group (n=30) and control group (n=30) and control group patients' carbamazepine treatment group patients application of gabapentin therapy, the comparison and analysis the clinical effect of two groups of patients with adverse reactions, and through the visual analog scale method for the treatment of patients with 1 week,2 weeks and 4 weeks after the level of pain were analyzed.Results Group therapy in patients with total effective rate is signiifcantly higher than the control group, the incidence of adverse reaction is signiifcantly less than the control group, two groups have statistical signiifcance; After VAS method, found in the two groups of patients after 1 week, 2 weeks, 4 weeks of no difference between the degree of pain, there is no statistical signiifcance. ConclusionGabapentin and carbamazepine treatment of primary trigeminal neuralgia were obvious curative effect, after comparing, the security of gabapentin as carbamazepine.%目的：探讨加巴喷丁与卡马西平治疗原发性三叉神经痛的临床效果，并分析其不良反应发生情况。方法将我院收治的60例原发性三叉神经痛患者作为本次研究对象，按照治疗方法的不同将其分为研究组（n=30）和对照组（n=30），给予对照组患者卡马西平治疗，研究组患者应用加巴喷丁治疗，对比分析两组患者的临床效果与不良反应情况，并通过视觉模拟标尺法对患者治疗后1周、2周以及4周的疼痛程度进行分析。结果研究组患者治疗总有效率高于对照组，不良反应发生率少于对照组，两组差异具有统计学意义；经VAS法分析后，发现两组患者在用药后1周、2周、4周的疼痛程度差异不存在统计学意义。结论加巴喷丁与卡马西平治疗原发性三叉神经痛均有疗效，相比较后，加巴喷丁的安全性优于卡马西平。