Objective To investigate the clinical features of renal impairment in patients with multiple myeloma(MM) and analyze the relevant factors. Methods Retrospective analysis of clinical data of 65 patients with MM . Renal function was evaluated by Cockcroft-Gault equations. According to the Ccr,Patients were divided into two groups:group A: Ccr<60mL/ min/( 1.73m2); group B:Ccr≥60mL/ min/(1.73m2). Then comparison of the clinical data between them.Results Compared with group B, group A beta-2 microglobulin, uric acid, blood calcium, urinary protein light chain, the incidence of anemia all higher (P<0.05). beta-2 microglob-ulin, uric acid, blood calcium, urinary protein light chain, hemoglobin levels all adverse renalfunction obviously. Conclusion Renal damage in MM has certain clinical features. IT have close relationship to beta 2 microglobulin, uric acid, blood calcium, urinary protein light chain, anemia.%目的:观察多发性骨髓瘤(MM)肾损害的临床表现及相关因素。方法回顾性分析我院65例MM患者临床资料,应用Cockcroft-Gault方程评估肾功能,按Ccr小于60mL/min/1.73 m2与大等于60mL/min/1.73m2将患者分为A、B两组,进行两组间临床资料的比较。结果 A组β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血发生率均高于B组,(P<0.05)。β2微球蛋白、尿酸、血钙、尿轻链蛋白、血红蛋白水平对肾功能均有明显影响。结论 MM肾损害有一定的临床特点,肾损害与β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血关系密切。
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