血浆APC对糖尿病肾病患者病情发生发展的影响

摘要

Objective to study the diabetic nephropathy patients plasma APC level impact on the occurrence and development of DN condition. Methods choose healthy check-up 35 cases as control group, 50 cases of diabetic patients hospitalized in our as cases, ELJSA method is used to detect the plasma level of APC and urine trace albumin concentrations, calculate 24 hours urine trace albumin levels and UAER. Results the cases of patients, creatinine, glycosylated hemoglobin, ALP, MAU and UAER in-creased significantly, while the APC level decreased significantly;Plasma APC level in patients with normal albuminuria group has no obvious change, microalbuminuria group decreased obviously, and clinical albuminuria group is significantly reduced. Conclu-sion APC level reduce is closely related to the happening of the disease of diabetic nephropathy development.%目的：研究糖尿病肾病患者血浆APC水平对DN病情发生发展的影响。方法选取健康体检者35例作为对照组，2012年1月—2014年1月该院住院治疗的糖尿病患者50例作为病例组，采用ELJSA法检测血浆APC水平和尿微量白蛋白浓度，计算24 h尿微量白蛋白含量及UAER。结果病例组患者肌酐、糖化血红蛋白、ALP、MAU和UAER明显升高，而APC水平显著降低；正常白蛋白尿组患者血浆APC水平无明显变化，微量白蛋白尿组明显降低，而临床蛋白尿组患者则极显著降低。结论APC水平降低与糖尿病肾病病情的发生发展密切相关。