丹川芪颗粒对稳定型心绞痛患者中医证候和血液流变学的影响

摘要

目的：探讨丹川芪颗粒对稳定型心绞痛气虚血瘀证患者中医证候和血液流变学的影响。方法整群选取2010年8月—2014年8月在该院门诊就治的80例稳定型心绞痛患者按照随机数字表法分为治疗组与对照组，两组在西医治疗基础上，治疗组给予丹川芪颗粒，对照组给予单硝酸异山梨酯。12周后观察两组中医证候疗效和血液流变学的变化。结果治疗组和对照组的心绞痛总有效率分别为87.5%和62.5%，差异有统计学意义(P<0.05)，治疗组和对照组的中医证候总有效率分别为82.5%和55.0%，差异有统计学意义(P<0.05)，治疗组血浆粘度、全血粘度高切、全血粘度低切水平治疗后较治疗前明显降低(P<0.05)。结论丹川芪颗粒能够改善稳定型心绞痛气虚血瘀型患者的中医证候，降低血流变学指标，从而提高稳定型心绞痛的治疗效果。%Objective To observe the effect of Dan Chuan Qi granules on TCM syndrome and hemorheology in patients with stable angina pectoris. Methods 80 outpatients with stable angina pectoris in our hospital between August 2010 and August 2014 were randomized into treatment group and control group according to random number table. The patients in the observation group were treated with Dan Chuan Qi granules, while those in the control group were treated with isosorbide mononitrate. Effects on TCM syndrome and hemorheology were observed 12 weeks after the treatment. Results The total effective rate in alleviating of angina pectoris was 87.5%in the observation group and 62.5%in the control group (P<0.05), and the difference was statistically signifi-cant. The total effective rate about TCM syndrome was 82.5%in the observation group and 55.0%in the control group (P<0.05). The blood viscosity, whole blood high shear viscosity, whole blood low shear viscosity were lower than those before treatment, and the differences were statistically significant(P<0.05). Conclusion For patients with Qi deficiency and blood stasis syndrome of sta-ble angina pectoris, Dan Chuan Qi granules can optimize therapeutic outcomes by improving their TCM syndrome and lowering the hemorheological parameters.