PICU多脏器功能衰竭综合征的临床治疗效果分析

摘要

目的：分析PICU多脏器功能衰竭综合征采用乌司他丁联合连续性血液滤过的临床治疗效果。方法随机选择2013年1月-2014年12月该院PICU收治的70例多脏器功能衰竭患儿作为研究对象，根据不同治疗方法，把70例患儿均分为两组，一组为对照组应用常规治疗与连续性血液滤过治疗，另一组为观察组应用乌司他丁联合连续性血液滤过治疗，比较两组患儿临床治疗效果。结果根据APACHEⅡ进行评分，观察组APACHEⅡ(7.3±1.7)、TNF-α(21.28±7.65)μg/L、TXB2(85.2±33.8)ng/L、BUN(8.0±2.2)mmol/L，各项指标明显优于对照组；观察组住院时间与重症监护室应用时间明显少于对照组，两组对比差异有统计学意义(P<0.05)。结论应用乌司他丁联合连续性血液滤过治疗多脏器功能衰竭临床疗效理想，可以明显减少PICU使用率，值得临床推广应用。%Objective To analyze the clinical effect of ulinastatin combined with continuous hemofiltration in the treatment of mul-tiple organ dysfunction syndrome in PICU. Methods 70 patients with multiple organ dysfunction syndrome admitted in PICU of our hospital during January 2013 and December 2014 were selected as the research object and divided, according to different treat-ment methods, into control group using routine treatment combined with continuous hemofiltration, and observation group adopting ulinastatin combined with continuous hemofiltration. The efficacies of the two groups were compared. Results According to A-PACHE II, APACHEII, TNF-α, TXB2, BUN in the observation group were (7.3±1.7),(21.28±7.65)μg/L,(85.2±33.8)ng/L,(8.0±2.2)mmol/L, respectively, which were superior to those in the control group; the hospitalization time and ICU stay of the observa-tion group were less than those of the control group. The differences above were statistically significant (P<0.05). Conclusion Uli-nastatin combined with continuous hemofiltration in the treatment of multiple organ dysfunction syndrome in PICU is worth promo-tion due to its shorter ICU stay and other good effects.