针对小儿心脏手术促红细胞生成素治疗和术前自体献血的临床研究

摘要

Objective The pediatric cardiac surgery erythropoietin (EPO) therapy and autologous blood donation launched preoper-ative clinical studies, provide a reference for future clinical therapy. Methods March 2010 - 2012 January to come to our hospital for pediatric cardiac surgery in children with 50 cases for the study were randomly divided into two groups and the control group, 25 patients in each group. Observation of patients in three days of continuous use before surgery erythropoietin treatment, and sub-cutaneous injection 100U/kg in accordance with the frequency of three times a week. Children need oral ferrous sulfate 60mg/d, taken twice a spare blood surgery. Children in the control group of blood in accordance with conventional equipment. Comparing two groups of children erythrocytes (RBC), hemoglobin (Hb), hematocrit (Hct), white blood cell (WBC), platelets (Plt) status. Re-sults After treatment, the situation of children in the study group than the control group. RBC group was observed in children is (4.01±1.86), the control group was (3.73±1.22); observed postoperative Hb was (114.11±1.12), the control group was (91.23± 1.72); observed postoperative Hct was (36.51±1.82), control group (29.86±1.43). Conclusion The higher the difficulty of pedi-atric heart surgery, through the application of erythropoietin therapy and preoperative autologous blood donation can improve the success rate of surgery, and rehabilitation of children in the future and growth have a greater positive significance in future clinical treatment application.%目的：对小儿心脏手术促红细胞生成素（EPO）治疗和术前自体献血展开临床研究，为日后的临床治疗提供参考。方法选择2010年3月—2012年1月前来该院进行小儿心脏手术患儿50例为研究对象，随机分为观察组及对照组，每组患者25例。观察组患者于术前3 d连续应用促红细胞生成素治疗，并且按照3次/周的频率进行皮下注射100 U/kg。患儿需口服硫酸亚铁60 mg/d，采2次血做手术备用。对照组患儿按照常规备血。对比两组患儿的红细胞（RBC）、血红蛋白（Hb）、红细胞压积（Hct）、白细胞（WBC）、血小板（Plt）状况。结果经过治疗后，观察组患儿的情况明显优于对照组。观察组患儿的术后RBC 为（4.01±1.86），对照组为（3.73±1.22）；观察组术后 Hb 为（114.11±1.12），对照组为（91.23±1.72）；观察组术后 Hct 为（36.51±1.82），对照组为（29.86±1.43）。结论小儿心脏手术难度较高，通过应用促红细胞生成素治疗以及术前自体献血，可提高手术的成功率，并且对患儿的日后康复和成长都具有较大的积极意义，日后可在临床治疗中推广应用。