长期家庭无创正压通气治疗对重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者稳定期的临床效果

摘要

Objective To treat chronic obstructive pulmonary disease complicated with type II respiratory failure in patients with chronic obstructive pulmonary disease by long-term home non-invasive positive pressure ventilation. Methods Conve-nient selection December 2007 to May 2014 come to our hospital treatment of severe patients with chronic obstructive pul-monary disease combined with type II respiratory failure in 120 cases for research object, according to the different treat-ment methods will be the into two groups,60 cases in each each patient, The control group received conventional drug ther-apy and long-term home oxygen therapy, the study group to implement noninvasive positive pressure ventilation in the treatment of these measures at the same time, the patient was discharged after two years of follow-up, clinical results were compared. Results When they were discharged from the hospital, two groups in the lung function and blood gas analysis do not exist significant differences,(P>0.05),no statistically significant; Two years later, the study group FEV1 score was (1.12± 0.18) points in the control group (0.76±0.22) points; PO2 in the study group for (68.54±5.89 mmHg), control group (47.07± 4.56) mmHg; PaCO2 in study group (42.12±12.13) mmHg, the control group (6.411±10.14) mmHg,large differences between the groups (P<0.05), statistically significant. The research group use breath agent when appear man-machine coordination and compressed facial injury, flatulence, and oropharyngeal drying and other adverse reactions, after instruction were effec-tively improved. Conclusion In patients with severe chronic obstructive pulmonary disease complicated with type II respira-tory failure during stable period of treatment, patients with long-term home non-invasive positive pressure ventilation treat-ment, can effectively relieve the clinical symptoms of patients.%目的：长期家庭无创正压通气治疗对重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者稳定期的临床效果。方法方便选取2007年12月-2014年5月来该院治疗重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的患者120例为研究对象,根据治疗方法的不同将其分为两组,每组患者60例,对照组接受常规药物治疗和长期家庭氧疗,研究组在采取上述措施的同时实施无创正压通气治疗,患者出院后随访两年,比较两组临床效果。结果出院时,两组在肺功能和血气分析情况等差异无统计学意义(P>0.05)；2年后,研究组FEV1评分为(1.12±0.18)分,对照组为(0.76±0.22)分；研究组PO2为(68.54±5.89)mmHg,对照组为(47.07±4.56)mmHg；研究组PaCO2为(42.12±12.13)mmHg,对照组为(64.11±10.14)mmHg,组间差异有统计学意义(P<0.05)；研究组使用呼气剂的时候出现人机不协调、面部压迫性损伤、胃肠胀气和口咽干燥等不良反应,经指导后均得到有效改善。结论在重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者稳定期治疗期间,给予患者长期家庭无创正压通气治疗,能够有效缓解患者临床症状。