大剂量沐舒坦对急性呼吸窘迫综合征患者肺损伤程度、血气指标和血清SOD活力的影响

摘要

Objective To study the high-dose mu comfortable for acute respiratory distress syndrome (ARDS) in patients with lung injury degree, the influence of the blood gas index and serum SOD activity. Methods Convenient selection in March 2014 - March 2016 in our hospital diagnosis and treatment of 120 cases of acute respiratory distress syndrome were randomly divided into observation group and control group, control group 450 mL saline implement static note, observe the group of 20 mg/kg mu comfortable plus 450 mL saline static note, compared two groups of serum superoxide dismutase (sod) activity and degree of lung injury in change. Results Observation group after lung injury and blood gas index score [7 d, PaO2/FIO2 to (352.1±53.2) mmHg;SaO2:(95.5±3.0)%;PaO2 (95.9±13.8)mmHg], compared with before treatment [(7 d, PaO2/FIO2 to(126.8±30.2)mmHg;SaO2:(89.1±4.9)%; PaO2:(65.4±10.2)mmHg], were improved significantly, serum SOD difference [(165.4 ±30.2) vs (146.1 ±28.1)] (P<0.05).Conclusion Using high doses of mu comfortable treatment in patients with acute respiratory distress syndrome, SOD activity significantly enhanced, breathable functional recovery.%目的：探讨大剂量沐舒坦对急性呼吸窘迫综合征(ARDS)患者肺损伤程度、血气指标和血清SOD活力的影响。方法方便选取2014年3月-2016年3月在该院诊治的急性呼吸窘迫综合征120例，随机分为观察组和对照组，对照组450 mL生理盐水实施静注，观察组20 mg/kg沐舒坦外加450 mL生理盐水静注，对比两组血清超氧化物歧化酶活力及肺损伤程度等变化。结果观察组用药后，肺损伤及血气指标评分[7 d：PaO2/FIO2为(352.1±53.2)mmHg；SaO2：(95.5±3.0)%；PaO2：(95.9±13.8)mmHg]相比于治疗前[(7 d：PaO2/FIO2为(126.8±30.2) mmHg；SaO2：(89.1±4.9)%；PaO2：(65.4±10.2)mmHg]，均得到显著改善，血清SOD活力两组比较差异有统计学意义[(165.4±30.2) vs (146.1±28.1)](P<0.05)。结论采用大剂量沐舒坦治疗急性呼吸窘迫综合征患者，可实现其血气指标和血清SOD活力的显著增强，利于呼吸功能恢复。