不同剂量左氧氟沙星治疗耐多药结核病临床疗效比较

摘要

Objective To compare different doses of levofloxacin in the treatment of multi drug resistant tuberculosis clini-cal curative effect. Methods Convenient selection of multi drug resistant tuberculosis patients in our hospital from July 2013 to October 2014. 80 cases were randomly divided into experimental group and control group. The control group of 40 cases, the use of levofloxacin dosage is 400 mg/d; 40 cases in the experimental group, the levofloxacin dose was 600 mg/d. compared two groups of patients with sputum negative conversion rate, and the incidence of adverse reactions in the treat-ment group. Results Sputum in patients with different stages of negative conversion rate is lower than the experimental con-trol group after treatment, and the total effective rate was 80% lower than the experimental group 92.5%, the difference was significant (P<0.05);the control group occurred in patients with poor the reaction rate was 17.5%, compared with 22.5%in the experimental group, no significant difference (P>0.05). Conclusion The effect of levofloxacin in patients with multi drug resistant pulmonary tuberculosis treatment significantly, the recommended dose is 600mg/d, conducive to disease control.%目的：比较不同剂量左氧氟沙星治疗耐多药结核病的临床疗效。方法方便选取该院2013年7月—2014年10月收治的80例耐多药结核病患者进行研究,随机分为实验组和对照组。对照组40例,采用左氧氟沙星剂量为400 mg/d；实验组40例,采用左氧氟沙星剂量为600 mg/d。比较两组患者痰菌阴转率、治疗效果与不良反应发生率。结果治疗后对照组患者不同时期的痰菌阴转率低于实验组,且治疗有效率80.0%低于实验组92.5%,差异有统计学意义（P<0.05）；对照组患者不良反应发生率17.5%,与实验组22.5%比较,差异无统计学意义（P>0.05）。结论给予耐多药肺结核患者左氧氟沙星治疗效果明显,推荐剂量为600 mg/d,利于病情控制。