大剂量盐酸氨溴索在重症肺炎集束化治疗中的应用效果

摘要

目的：评价大剂量氨溴索在集束化治疗重症肺炎中的应用价值。方法整群选取该院2014年6月—2015年3月期间接收入院的重症肺炎患者84例随机分为对照组和实验组两组，每组42例。对照组采用常规剂量氨溴索治疗，实验组采用大剂量氨溴索治疗。比较两组治疗效果、肺功能的恢复情况及抗感染的效果。结果实验组住ICU时间(12.2±1.6)d、使用呼吸机时间(10.8±1.4)d、PaO2（95.3±0.3）mmHg、SPO2（96.7±1.2）%、PaO2/FiO2（314.7±5.3）mmHg、降钙素（0.51±0.36）、C反应蛋白（30.87±0.74）优于对照组，差异有统计学意义（P<0.05）。结论对重症肺炎患者进行大剂量氨溴索集束化治疗，可以明显患者的抗感染能力，改善患者的通气功能，治疗效果明显，值得在临床进行广泛应用。%Objective To evaluate the application value of large dose of ambroxol hydrochloride in treatment of severe pneumonia in the cluster. Methods Group selection 84 patients admitted to hospital during June 2014 to March 2015 were randomly divided into two groups of the control group and the experimental group, each 42 patients. The control group used conventional dose ambroxol treatment, the experimental group received a large dose of ambroxol treatment. The treatment effect, the recovery of lung function and the effect of anti infection of the two groups were compared. Results Experimental duration of ICU stay (12.2 ± 1.6)d, ventilator time (10.8 ± 1.4)d, PaO2(95.3 ± 0.3)mmHg, SPO2 (96.7 ± 1.2)%, PaO2 / FiO2 (314.7 ± 5.3)mmHg, calcitonin (0.51 ± 0.36), C-reactive protein (30.87 ± 0.74) better than the control group, with statistical significance (P<0.05). Conclusion High dose ambroxol bundle treatment of severe pneumonia patients, can obviously resist Infection ability, improve the ventilation function of patients, the treatment effect is obvious, it is worth to be widely used in clinical practice.