药物治疗对有无缺血预适应患者的急性心肌梗死溶栓再通率及左心室射血分数的影响

摘要

Objective To study the effect of drug therapy on acute myocardial infarction thrombolytic recanalization rate and left ventricular ejection fraction in patients with and without ischemic preconditioning. Methods A total of 70 patients with acute myocardial infarction admitted from January 2010 to January 2017 were selected as subjects for study. They were divided into groups according to their history of ischemic preconditioning, including 35 patients with ischemic preconditioning as the observation group and 35 patients without ischemic preconditioning as the control group. All patients were given a one-time thrombolysis of 1.5 million IU. The incidence, mortality, recanalization rate, peak concentration of creatine kinase, left ventricular ejection fraction, cardiac output, cardiac index and cardiac pulse index were compared between the two groups. Results Comparing with the control group, the complication rate and fatality rate of the observation group were lower, and the difference was statistically significant (P < 0.05). The vascular recanalization rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05). The peak concentration of creatine kinase in the observation group was lower than that in the control group, the left ventricular ejection fraction was higher than that in the control group, and the cardiac output, cardiac index and heart beat index were higher than those in the control group. The difference was statistically significant (P < 0.05). Conclusion The effect of ischemic preconditioning on AMI thrombolysis recanalization rate and LVEF is significant, which can accurately reduce complications and mortality, effectively improve thrombolysis recanalization rate, and improve its cardiac function and other indicators.%目的 研究药物治疗对有无缺血预适应患者的急性心肌梗死(acute myocardial infarction,AMI)溶栓再通率及左心室射血分数(left ventricular ejection fraction,LVEF)的影响.方法 选取2010年1月—2017年1月收治的70例急性心肌梗死患者作为研究对象.根据其有无缺血预适应史进行分组,其中,有缺血预适应35例作为观察组,无缺血预适应35例作为对照组.所有患者均一次性给予尿激酶150万IU溶栓.对比两组并发症发生率、死亡率、血管再通率、肌酸激酶峰值浓度、左心室射血分数、心输出量、心脏指数、心搏指数.结果 与对照组相比,观察组并发症发生率及病死率较低,组间对比,差异具有统计学意义(P＜0.05);观察组血管再通率与对照组相比明显要高,组间对比,差异具有统计学意义(P＜0.05).观察组肌酸激酶峰值浓度低于对照组,左心室射血分数高于对照组,心输出量、心脏指数、心搏指数均高于对照组,组间对比,差异具有统计学意义(P＜0.05).结论 缺血预适应对AMI溶栓再通率及LVEF的影响较大,可准确减少并发症及病死率,有效提高溶栓再通率,并使其心功能等指标进行改善.