目的探讨阿昔洛韦联合糖皮质激素治疗Bel氏麻痹的预后。方法选取我院2014年2月～2015年2月Bel麻痹患者58例作为研究对象。在常规联合皮质类固醇以及B族维生素、针灸康复治疗的基础上，根据阿昔洛韦抗病毒治疗及发病至使用抗病毒药物的时间不同，将所有患者分为3天内使用阿昔洛韦组、3天后使用阿昔洛韦组、未使用阿昔洛韦组，保持随访1年时间，收集临床资料。应用House-Brackmann（HB）面神经功能评分评估分析三组的预后情况。结果经过统计，3天内使用阿昔洛韦组的完全康复率较其余两组高，差异均具有统计学意义（P＜0.05）；3天后使用阿昔洛韦组患者的恢复情况与未使用阿昔洛韦组对比，差异无统计学意义（P＞0.05）；3天内使用阿昔洛韦组患者完全恢复的时间均短于其他两组，差异均具有统计学意义（P＜0.05）；3天后使用阿昔洛韦组患者的恢复时间与未使用阿昔洛韦组对比（P＜0.05）。结论阿昔洛韦是治疗Bel麻痹的有效手段，而早期应用阿昔洛韦（3天内）对良好预后有明确的意义，而推迟应用可能影响治疗效果。%Objective To explore the prognosis of acyclovir combined with glucocorticoids in the treatment of Bell's palsy.Methods 58 cases of Bell palsy in our hospital from February 2014 to February 2015 were selected as the research objects. In combination with conventional corticosteroid and B vitamins, on the basis of acupuncture and rehabilitation therapy, according to acyclovir antiviral therapy and the incidence to the use of antiviral drugs in different time, all patients were divided into acyclovir group within 3 days, 3 days after the use of acyclovir, without the use of acyclovir to maintain a follow-up of 1 years and to collect clinical data. The prognosis of three groups was evaluated by House-Brackmann (HB) facial nerve function score.Results After statistics, fully recovered within 3 days of acyclovir group compared with other two groups of high rate, the difference was statistically significant (P < 0.05). And without the use of acyclovir group contrast recovery group after 3 days of use of acyclovir,the difference was not statistically signiifcant (P > 0.05). Within 3 days of acyclovir group of patients with complete recovery time was shorter than the other two groups, the difference was statistically signiifcant (P< 0.05). 3 days after using the recovery time of patients with and without the use of acyclovir acyclovir group (P < 0.05). Conclusion Acyclovir is effective in treating Bell palsy, the early use of acyclovir (within 3 days) have a clear meaning of good prognosis, and delayed application may affect the treatment effect.
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