The present invention addresses secondary adrenal dysfunction by co-administering a therapeutically effective amount of a glucocorticoid and a therapeutically effective amount of a glucocorticoid receptor antagonist to a patient in need of treatment for secondary adrenal dysfunction. Provide a method of treatment. In some embodiments, the method comprises a condition that the patient does not otherwise require treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method may increase the patient's early morning or basal cortisol levels to at least about 12 μg / dL or standard control levels, and then significantly promote HPA axis recovery. The methods provided herein can improve health outcomes and fatal complications associated with secondary adrenal dysfunction.
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