健康成人血清胱抑素C水平与颈动脉粥样硬化的相关性研究

摘要

Objective To take healthy adults as the object, to investigate the correlation between carotid atherosclerosis and serum cystatin C. Methods 256 cases of healthy adults were chosen in our hospital, carotid ultrasonic examination and serum biochemical tests, according to the examination results of the carotid artery, which can be divided into carotid atherosclerosis group (80 cases) and carotid IMT normal group (176 cases), two groups of serum cystatin C levels and other indicators of change, and regression analysis the related factors of carotid atherosclerosis.Results Atherosclerosis group age, diastolic blood pressure, systolic blood pressure, serum cystatin C, total bilirubin, creatinine, urea nitrogen, total cholesterol, low density lipoprotein were significantly higher than the normal group(P<0.05).Logistic regression analysis, carotid intima-media thickening and plaque formation (or) age, systolic pressure, low density lipoprotein exists related (P<0.05).Conclusion Between healthy adult serum cystatin C is associated with carotid atherosclerosis has not been fully confirmed, but also the need for further discussion.%目的：以健康成人为对象，对其颈动脉粥样硬化与血清胱抑素C相关性进行探讨。方法选取我院健康体检成人256例，行颈动脉彩超检查与血清生化检验，根据颈动脉检查结果，将其分为颈动脉粥样硬化组（80例）和颈动脉内膜正常组（176例），对两组血清胱抑素C含量及其他指标变化，并回归分析影响颈动脉粥样硬化的相关因素。结果颈动脉粥样硬化组年龄、舒张压、收缩压、胱抑素C、总胆红素、肌酐、尿素氮、总胆固醇、低密度脂蛋白均高于颈动脉内膜正常组（P＜0.05）；Logistic回归分析，颈动脉内膜中层增厚和（或）斑块形成年龄、收缩压、低密度脂蛋白存在相关性（P＜0.05）。结论健康成人血清胱抑素C与颈动脉粥样硬化之间相关性未得到充分证实，还需要作进一步探讨。