目的：比较含或不含奥硝唑四联方案用于对青霉素过敏的幽门螺杆菌感染者的临床疗效及不良反应。方法将111例Hp感染者随机分为两组，A组（治疗组55例）给予雷贝拉唑10 mg、奥硝唑500 mg、左氧氟沙星200 mg、胶体果胶铋200 mg；B组（对照组56例）给予雷贝拉唑10 mg、克拉霉素500 mg、左氧氟沙星200 mg、胶体果胶铋200 mg；均2次/d给药，疗程10 d。结束后4周复查，比较两组Hp根除成功率及两组不良反应发生率及价格成本。结果两组Hp根除成功率A组为89.1%（49/55）、 B组为80.4%（45/56），两组比较差异有统计学意义（P＜0.05）；两组不良反应发生率A组为3.63%（3/55）、B组为12.5%（7/56），两组比较差异有统计学意义（P＜0.05）。结论含奥硝唑四联方案用于青霉素过敏者根治Hp有效且不良反应较少。%Objective To observe the effects and adverse reactions of omidazole-containing quadruple therapy in the eradication of helicobacter pylori. Methods111 patients with HP infection were randomly divided into two groups, group A (treatment group 55 cases) given rabeprazole 10 mg, ornidazole 500 mg, levolfoxacin 200 mg, colloidal bismuth pectin 200 mg, group B (control group 56 cases) was given rabeprazole 10 mg, clarithromycin 500 mg, levofloxacin 200 mg, colloidal bismuth pectin 200 mg, twice daily administration. The treatment course was 10 days. 4 weeks after the end of the review, compare the two groups Hp eradication success rate and the incidence of adverse reactions and two sets of price costs.Results Two groups of Hp eradication success rate of group A was 89.1% (49 / 55), group B was 80.4% (45 / 56), the difference between the two groups has statistical significance (P<0.05). The adverse reactions of the two groups occurred rate of group A was 3.63% (3 / 55), group B was 12.5% (7 / 56), the difference between the two groups has statistical signiifcance (P<0.05).Conclusion Ornidazole contained quadruple therapy for penicillin allergy cure Hp effective and less adverse reactions.
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