抗乙肝高效免疫球蛋白联合乙肝疫苗对乙肝母婴垂直传播的预防效果分析

摘要

目的：研究分析抗乙肝高效免疫球蛋白联合乙肝疫苗对乙肝母婴垂直传播的预防效果。方法选取我院所接收的56例患有乙型肝炎孕妇，将其分为对照组28例和观察组28例两组，观察分析两组的预防效果。结果观察组对乙肝母婴垂直传播的预防效果显然优于对照组，其中对照组患者的HBsAg阳性率、抗-HBs阳性率、HBV-DNA阳性率分别为：5（17.8%）、6（21.4%）、8（28.5%）；观察组患者的HBsAg阳性率、抗-HBs阳性率、HBV-DNA阳性率分别为：1（3.5%）、1（3.5%）、2（7.1%），对比两组患者的HBsAg阳性率、抗-HBs阳性率、HBV-DNA阳性率，χ2分别为3.19、4.23、6.72，差异具有统计学意义（P＜0.05）。结论抗乙肝高效免疫球蛋白联合乙肝疫苗对乙肝母婴垂直传播有着较好的预防效果，有利于新生儿的身体健康发育。%Objective To study the effect of hepatitis B vaccine combined with hepatitis B vaccine on prevention of vertical transmission of hepatitis B virus. Methods Selected 56 patients with hepatitis B in our hospital were divided into control group 28 cases and observation group two cases of 28 groups, the observation and analysis of the prevention effect of the two groups. Results The prevention effect of the observation group on the vertical transmission of hepatitis B is obviously better than that of the control group. In the control group, the positive rate of HBsAg, anti-HBs positive rate, HBV-DNA positive rate were 5 (17.8%), 6 (21.4%), 8 (28.5%), respectively;The positive rate of HBsAg, anti-HBs positive rate and HBV-DNA positive rate in the observation group were 1 (3.5%), 1 (3.5%), 2 (7.1%). Preventive effect of observation group was obviously better than that of the control group,χ2 were 3.19, 4.23, 6.72 respectively, the difference was statistically significant (P<0.05). Conclusion Anti-hepatitis B high effective immunoglobulin combined with hepatitis B vaccine has a good effect in preventing the transmission of hepatitis B, which is conducive to the healthy development of the newborn.