目的：对初次单侧膝关节置换围手术期局部应用氨甲环酸对出血量的影响进行探讨，并掌握其用药安全性。方法以我院关节外科收治的40例初次单侧膝关节置换术患者作为研究对象，随机分成M组和N组，均为20例；M组局部应用氨甲环酸；N组局部应用生理盐水，对两组的失血量及术后并发症发生情况予以分析。结果两组术后24 h、48 h的引流量、血红蛋白水平及术后总失血量，差异均有统计意义（P＜0.05）；在治疗中两组均未出现不良反应。结论在初次单侧膝关节置换围手术中，局部应用氨甲环酸可有效减少围术期失血量，促进患者术后恢复，未增加感染、静脉血栓发生风险，安全性较高。%Objective For primary unilateral knee replacement around tranexamic acid on blood loss affect the operation of the local application of ammonia to explore, and master their drug safety. Methods 40 cases of primary unilateral knee replacement patients in joint surgery in our hospital were chose as research subjects, were randomly divided into groups M and N group, 20 cases in each group, M group topical application of tranexamic acid, N group topical application of saline, two groups of blood loss and postoperative complications were to be analyzed. Results Two groups of postoperative 24 h, 48 h of the drainage volume, hemoglobin level and total blood loss, the difference was statistically signiifcant (P<0.05), in the treatment of the two groups were not adverse reactions. Conclusion In primary unilateral knee replacement surgery around, the local application of tranexamic acid may be effective in reducing perioperative blood loss, postoperative recovery promote me, did not increase the infection, the risk of venous thrombosis, high security.
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