Objective To compare the efficacy of nasal intermittent positive pressure ventilation (NIPPV) with nasal continuous positive airway pressure (NCPAP) in neonatal respiratory distress syndrome (NRDS). Methods 80 cases of NRDS in our hospital were randomly divided into two groups, and were applied NCPAP and NIPPV, respectively. The situation of arterial blood gas analysis and complication rate in two groups were compared. Results After 12 h, the pH, PaO2, PaCO2 of children in the observed group were better than the control group (P<0.05). Complication rate of observed group was 15.0%, significantly lower than the control group 32.5% (P<0.05). Conclusion Compared with NCPAP and NIPPV in treatment of children with NRDS, NIPPV is efficacy and safety better.%目的：对比分析经鼻间歇性正压通气（NIPPV）与经鼻持续正压通气（NCPAP）对新生儿呼吸窘迫综合征（NRDS）的疗效情况。方法应用随机数字表将我院80例 NRDS 患儿随机分为两组，分别应用 NCPAP 及 NIPPV ；对比两组患儿动脉血气分析情况及并发症发生率。结果治疗12 h 后，观察组患儿的 pH 值、PaO2、PaCO2均优于对照组（P ＜0.05）。观察组并发症发生率为15.0%，明显低于对照组32.5%（P ＜0.05）。结论与 NCPAP 相比，采用 NIPPV 治疗 NRDS患儿的疗效及安全性更佳。
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