绝经前系统性红斑狼疮合并骨质疏松症患者血清中RANKL表达水平及临床意义

摘要

Objective To investigate the clinical significance of premenopausal patients with systemic lupus erythematosus (SLE) complicated with osteoporosis (OP) the RANKL changes. Methods Total of SLE and OP with prior diagnosis of premenopausal female patients the 26 cases of OP group, selected the premenopause patients with SLE without OP and 26 cases of N-OP group, another randomly selected the same period 26 cases of premenopausal female healthy subjects, and the level of RANKL was determined by ELISA method.Results The level of RANKL in SLE group was signiifcantly higher than that of the control group (P<0.05), patients with OP group RANKL levels were higher than N-OP group (P<0.05).Conclusion RANKL plays an important role in the occurrence of OP on SLE patients, so the measurement of the indicators, which can effectively for diagnosis for SLE with OP.%目的：探讨绝经前系统性红斑狼疮（SLE）合并骨质疏松症（OP）患者血清中的RANKL表达水平及临床意义。方法纳入确诊SLE且合并OP的绝经前女性患者26例为OP组，选取无OP的绝经前SLE患者26例为N-OP组，另26例非绝经期女性健康体检者为健康对照组，并以ELISA法测定研究对象血清中RANKL水平。结果 SLE组RANKL水平高于健康对照组，合并OP组与未合并OP组RANKL水平均高于健康对照组（P＜0.05），且合并OP组RANKL水平高于未合并OP组（P＜0.05）。结论绝经前SLE合并OP患者常伴有血清RANKL水平升高，高RANKL水平可能为绝经前SLE患者OP发生的独立危险因素。