Synthesis and Stereochemistry of New Cyclic Phosphate-phosphonates

摘要

The novel cyclic phosphate-phosphonatds, cis/trans-2-phosphonobenzyloxy-4-5, 5-dimethyl-1, 3. 2-dioxaphosphorinane 2-sulfides(selenides) (7a-f),were synthesized by a one-pot reaction using tris(diethylamino)phosphine activated by iodione as the phosphorylating and ring-closing reagent in good overall yields. The geometric stereoisomers were isolated and characterind A cisconfiguration and a chair preferred conformation of -one isomer of 7b were established ty X-ray diffraction analysis.