The Ephemeral 10β-OH Trifluoromethanesulfonates of 7-Epi Paclitaxel Analogs─A New Example for Anchimeric Assistance

摘要

Two rearranged products, dienone 4 and 10-oxo product 5 were obtained upon attempted 10β-OSO2SO2CF3 formation from 3. The formation of compound 5 can be explained by anchimeric assistance of 7α-OH. Reduction of 4 yielding a 4-deacetyl product (12) also involves neighboring group participation.