噬菌体展示技术及其在动物病毒性疾病中的应用

摘要

Phage display is the technology that allows expression of exogenous (poly) peptides on the surface of phage particles. In recent years, phage display technology has made a great progress in applications about animal viral diseases, and showed a clear advantage in some areas, such as screening viral epitope, antiviral peptides and vaccine design et al. This review focuse on introducing its theory and applications in viral diseases. And hope to make a guide to follow-up study.%噬菌体展示技术是在20世纪80年代中期兴起的一项技术,该技术可以实现外源蛋白质或多肽基因的表达产物与噬菌体衣壳蛋白融合,进而展示到噬菌体表面.近年来,噬菌体展示技术在动物病毒性疾病中的应用范围越来越广,在筛选动物病毒抗原表位及抗病毒多肽、疫苗研制等领域显示出了明显的优势.文章就噬菌体展示技术的基本原理及噬菌体展示技术在动物病毒性疾病方面的应用作一综述,以期对后续噬菌体展示技术在病毒性疾病的诊断、防制等方面的应用作指导.