吡喹酮注射液对水牛血吸虫病的临床治疗效果

摘要

采用粪便毛蚴孵化法筛选自然感染血吸虫病水牛,考察30％吡喹酮注射液对水牛血吸虫病的临床治疗效果.在实验性临床试验中,将自然感染血吸虫病水牛随机分为5组,分别为吡喹酮注射液高(20 mg/kg)、中(10 mg/kg)、低(5 mg/kg)剂量组,吡喹酮片组(30 mg/kg)和阳性对照组(不用药组).给药30 d后,吡喹酮注射液高、中、低剂量组及吡喹酮片组的粪便毛蚴孵化转阴率分别为100.0％、100.0％、77.8％和85.7％.在扩大临床试验中,将自然感染血吸虫病水牛随机分为2组,分别为吡喹酮注射液推荐剂量组(10 mg/kg)和吡喹酮片组(30 mg/kg),给药30 d后,吡喹酮注射液组的52头患牛的粪便毛蚴孵化转阴率为100％,吡喹酮片组的6头患牛的粪便毛蚴孵化转阴率为100％.研究结果表明,30％吡喹酮注射液对水牛血吸虫病具有良好的治疗效果,给药方便,可以替代传统内服片剂,临床推荐剂量为10 mg/kg.%To observe the clinical therapeutic effect of 30％ praziquantel injection on buffalo schis-tosomiasis,the sick buffalos naturally infected with Schistosoma j aponicum were selected by miracidium hatching method.In experimental clinical trials,sick buffalos were randomly divided into five groups,high-dose (20 mg/kg),middle-dose (10 mg/kg)and low-dose (5 mg/kg)praz-iquantel injection groups,praziquantel tablet group (30 mg/kg)and positive control group.After the treatment of 30 d,the negative conversion rate of miracidium were 100.0％,100.0％,77.8％and 85.7％,respectively,in praziquantel injection groups with the high,middle and low dose and oral medication group.In expanded clinical trials,the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg).The results showed that,the negative conversion rate of miracidium were all 100％in the former 52 patients and the latter 6 patients after 30 d.The research confirmed that praziqu-antel injection was significantly effective in the treatment of buffalo schistosomiasis and conven-ient for administration.It was concluded that 30％ praziquantel injection could replace the tradi-tional oral praziquantel tablet for the treatment of buffalo schistosomiasis,and the recommended dose was 10 mg/kg.