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SCHISTOSOMICIDAL COMPOSITIONS COMPRISING OXAMNIQUINE AND PRAZIQUANTEL
SCHISTOSOMICIDAL COMPOSITIONS COMPRISING OXAMNIQUINE AND PRAZIQUANTEL
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机译:包括苯甲酰胺和吡喹酮的血吸虫病成分
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摘要
Schistosomicidal compositions containing a compound of the formula:- …CHEM… wherein R1 and R2 each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;… R3 is nitro, cyano, fluorine, chlorine, bromine or iodine,… and R4 is methyl or hydroxymethyl;… or a pharmaceutically acceptable acid addition salt thereof;… and a compound of the formula:- …CHEM… wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism. …??Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II).
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