细胞因子佐剂研究进展

摘要

佐剂可通过增强巨噬细胞活性促进机体 T 细胞或 B 细胞的反应，参与半抗原或抗原免疫应答。随着人们对疫苗免疫效果的研究，细胞因子作为新型分子佐剂能增强疫苗的特异性免疫反应而被广泛研究。细胞因子在调节先天免疫和适应性免疫中发挥着关键作用，能增强疫苗的特异性免疫反应。最近几年，白细胞介素、干扰素、粒细胞巨噬细胞集落刺激因子、肿瘤坏死因子、趋化因子的研究已取得了很大进展，现对细胞因子佐剂的应用进展进行阐述，以期为其在将来的应用中提供参考。%As an adjuvant,cytokine plays a key role in regulating the innate and adaptive immuni-ty and enhancing the vaccine specific immune responses.The researches on the interleukin,inter-feron,granulocyte macrophage colony stimulating factors,tumor necrosis factors,and chemotac-tic factor have made considerable progress.Now we reviewed the cytokine adjuvant application in order to provide reference for the future application.