生态友好材料聚乳酸的合成研究进展

摘要

Synthesis and application of polylactic acid (PLA), a kind of eco-friendly polymers possessing excellent biocompatibility and biodegradability, has recently attracted greatly attention. PLA is manufactured by two methods, i. e. polycondensation and ring-opening. Commercially the catalysts used for the synthesis of PLA are stannous compounds as stannous chloride dehydrate, and stannous octoate. Research revealed that the stannous compounds are cytotoxic that has aroused concern about the bio-safety of the materials based on PLA and its use in humans. Key advances in synthesis of PLA were reviewed.%聚乳酸（PLA）是一种具有高度生物相容性、生物可降解性的环境友好型材料,其合成方法及应用研究日益受到关注。聚乳酸的合成主要有两种方法：缩聚和开环。商品化聚乳酸合成中所使用的催化剂主要为锡类化合物,例如二水合氯化亚锡和辛酸亚锡。研究表明锡类化合物具有一定的生理毒性,因而引起了人们对聚乳酸材料的生物安全性以及其在人体中使用的关注。本文综述了近年在生物降解性聚乳酸类材料的合成方面的重要研究进展。