抗肿瘤蕈类多糖的研究进展

摘要

Mushrooms are recognized as functional foods and have credible nutritional and medicinal values. Polysaccharide is one of the most bioactive components in mushrooms and exhibits anti-tumor and immunostimulating activities. Numerous polysaccharides with anti-tumor activity have been extracted from a variety of mushrooms, but there are many differences in their chemical composition, structure and anti-tumor activity. This review aims to integrate the R&D progress of anti-tumor polysaccharides in mushrooms which include mushroom polysaccharides with anti-tumor activity, chemistry of mushroom polysaccharides, relationship between structure and anti-tumor activities of mushroom polysaccharides, anti-tumor activity and mechanisms of mushroom polysaccharides. And this review also looks forward to the future studies on receptors and signal transduction pathway, structure activity relationship and pharmacokinetics of polysaccharides.%蕈类被视为功能性食物，具有营养和药用价值，多糖是蕈类中的主要活性物质，具有抗肿瘤和增强免疫的作用。蕈类多糖由于来源广泛，其在化学结构和抗肿瘤活性方面存在较大差异。文章从具有抗肿瘤活性的蕈类多糖、抗肿瘤蕈类多糖的结构特征、蕈类多糖结构与抗肿瘤活性的关系、蕈类多糖的抗肿瘤作用及机制4个方面综述了抗肿瘤蕈类多糖的研究进展。并进一步从多糖受体相关的信号转导通路研究、构效关系研究、代谢动力学研究3个方面进行了展望。