A series of 2-methyl-5-phenylthio-l,3,4-thiadiazole compounds were synthesized using substituted iodobenzene and 5-methyl-l,3,4-thiadiazole-2-thiol as raw materials.The optimum conditions were obtained as follows:using Cul as catalyst and 2-picolinic acid as ligand in dimethyl sulfoxide at 70~80℃ for 24~36 h.The structures of target compounds were confirmed by 1HNMR,13CNMR,IR,MS.%以取代碘苯和2-巯基-5-甲基-1,3,4-噻二唑为原料,合成了一系列2-甲基-5-取代苯硫基-1,3,4-噻二唑类化合物,确定最佳合成条件为:以碘化亚铜作催化剂、2-吡啶甲酸作配体,于70～80℃在二甲基亚砜中反应24～36 h.目标化合物结构经核磁共振氢谱、核磁共振碳谱、红外光谱、质谱分析确证.
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