荧光碳点纳米材料对大肠杆菌的毒性研究

摘要

以革兰氏阴性菌大肠杆菌为实验模型，采用微量热法研究了碳点对细菌生长的生物效应。低浓度的碳点（0.00～5.00 mg·L－1）使得细菌的最大热功率（P peak ）和总热量（Qtotal ）增大。碳点对大肠杆菌的半抑制浓度（IC50）为18.53 mg·L－1。碳点对大肠杆菌生长的影响与其浓度有关。%In this study,Gram-negative bacteria Escherichia coli (E.coli)was applied as testing model to study the biological effect of carbon dots(Cdots)on the cell growth by microcalorimetry.The introducing of Cdots caused a gradual increase of maximum heat power(P peak)and total heat produced(Qtotal)at low concentra-tions(0.00~5.00 mg· L-1 ).Half inhibitory concentration(IC50 )of Cdots was 18.53 mg· L-1 .Cdots had a concentration-dependent effect on the growth of E.coli.