基于 Wnt/β-catenin 信号通路的骨质疏松靶向治疗研究进展

摘要

Wnt/β-catenin 信号通路在胚胎发育、成人组织稳态以及组织再生等方面发挥着重要作用，同时对骨形成也起着重要的促进作用。随着 Wnt/β-catenin 信号通路在骨质疏松中作用的阐明，针对 Wnt/β-catenin 信号通路的靶向治疗已经成功地应用于临床。对基于 Wnt/β-catenin 信号通路的骨质疏松靶向治疗进行了综述，为抗骨质疏松药物的设计提供了理论依据。%Wnt/β-catenin signaling pathway plays important roles in embryogenesis,adult tissue homeostasis and tissue regeneration.It also plays an important role in promoting bone formation.With the clarification of Wnt/β-catenin signaling pathway in osteoporosis,targeted therapies through this pathway have been successful-ly used in clinical applications.The targeted therapies based on Wnt/β-catenin signaling pathway in osteoporosis are reviewed,which can provide a theoretical basis for drug design.