β-淀粉样多肽自聚集抑制剂的电化学筛选方法研究

摘要

β-淀粉样多肽（Amyloid beta, Aβ）的聚集物具有神经细胞毒性，可导致神经元凋亡，从而诱导阿尔茨海默症（Alzheimer’s disease, AD）的发生。能够抑制Aβ自聚集行为的化合物称为Aβ自聚集抑制剂。该抑制剂可抑制Aβ有毒聚集物的产生，从而降低Aβ所引起的神经细胞毒性，对AD病有一定的治疗效果。因此，筛选Aβ自聚集抑制剂对于AD的治疗有着重要的意义。在数以千万计的化合物中，要筛选出对Aβ自聚集有抑制效果的化合物需要借助众多的仪器和研究方法。该文总结了筛选Aβ自聚集抑制剂的几种方法，重点综述了几种低成本、快速、灵敏的电化学筛选方法。 Aβ自聚集抑制剂的筛选对临床上AD病的治疗提供了理论基础，为治疗AD病这一复杂科学问题的研究起到了促进作用。%Amyloid beta (Aβ) peptides and their aggregates are believed to be toxic to the neuron and partially responsible for the etiology of Alzheimer’s disease (AD). The aggregate-inflicted cellular toxicity can be inhibited by aggregation inhibitors. Screening of drugs for inhibiting the aggregation of Aβ peptides is important for the therapeutic treatment of AD. This review addresses several methods for screening aggregation inhibitors of Aβ, with emphasis placed on rapid and sensitive electrochemical methods. Screening the Aβaggregation inhibitors is of great therapeutic significance for AD.